Reprotox Biotech was awarded the RDTSS Best Paper in Toxicological Science in 2025. The paper entitled as High-content Toxicological Profiling of 87 Compounds Using a 3D Mouse Mini-Testis Model as A New Approach Methodology (NAM) for Prioritizing Male Reproductive Toxicants, Lei Yin, Jamie Chelin Hu, Menghang Xia, Xiaozhong John Yu Reprotox Biotech LLC, Albuquerque, NM 87106, United State, College of Nursing, University of New Mexico, Albuquerque, NM 87106, United States. ; National Center for Advancing Translational Sciences (NCATS), NIH, Bethesda, MD, United States.

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Mar 2026

Reprotox proudly attended the Next Frontier event on March 3, 2026, in Albuquerque, New Mexico, hosted by the New Mexico Economic Development Department. The event celebrated innovation, brought together leaders shaping the state’s science and technology economy, and inspired new opportunities to explore the frontier and grow the future.

Reprotox Biotech LLC was awarded the FY26 New Mexico Science and Technology Business Startup Grant on October 27, 2025, by the Technology Research Collaborative Board and the New Mexico Economic Development Department, recognizing the company’s innovation in biotechnology and scientific advancement in New Mexico.

Reprotox attended the 10th Annual Knowledge Fair, Advancing Life Science & Health Innovation, hosted by the New Mexico Biotechnology & Biomedical Association at CNM’s Workforce Training Center in Albuquerque, NM.

Reprotox filed UNITED STATES NON-PROVISIONAL PATENT APPLICATION (US Patent 72332695). TITLE: High-content Toxicological Profiling of 87 Compounds Using a 3D Mini-Testis Model: A New Approach Methodology (NAM) for Prioritizing Male Reproductive Toxicants.

Reprotox received the NIH Complement-ARIE Challenge Prize Award in 2025, recognizing its innovative contribution to New Approach Methodologies (NAMs) for modeling human biology. The NIH competition selected 20 winning teams nationwide for advancing in silico, in vitro, in chemico, and combinatorial approaches.

High-quality canine and rat Sertoli cells available for researchers

Sertoli cells play critical roles in regulating spermatogenesis and testis development by providing structural and nutritional support. This study aimed to develop a standard protocol for canine Sertoli cell isolation and culture and to characterize its biological features, functionality, and applications in compound toxicity testing. Canine testicles were received from the neuter clinic, and a three-step enzymatic digestion process was applied to isolate Sertoli cells. We characterized the growth and purity of Sertoli cells by the expression of SOX9, GATA4, and Clusterin. In addition, cadmium was selected as a model toxicant to evaluate toxic responses in newly established Sertoli cells using High-Content Analysis (HCA). With our optimized protocol, the purity of isolated Sertoli cells was above 95%, as determined by Sertoli cell-specific protein markers SOX9 and GATA4.

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Mar 2023

Dr. Lei Yin delivered an invited talk entitled "High-Content Imaging Analysis for Testicular Toxicity Prediction Using an 87-Compound Library in a Three-Dimensional Testis Model — Building Integrated In Vitro Models for Predicting In Vivo Testing" at the 40th Mountain West SOT Meeting in Santa Fe, NM (2022).

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Aug 2022

High-content image-based analysis of endocrine disruptors

We published a manuscript titled "High-content analysis of testicular toxicity of BPA and its selected analogs in mouse spermatogonial, Sertoli cells, and Leydig cells revealed BPAF induced unique multinucleation phenotype associated with increased DNA synthesis". This study examined the selective toxicity of BPA, BPS, BPAF, and TBBPA in testicular cells, including Sertoli, Leydig, and spermatogonial cells. We developed a high-content image-based single-cell analysis platform and measured a broad spectrum of adverse endpoints related to reproductive toxicology.

Reprotox attended the New Mexico Humane Conference on August 11, 2022. Our company has been developing novel in vitro models that promise to improve animal welfare and reduce the number of animals needed in future research. We look forward to meeting New Mexico animal welfare advocates and finding collaboration opportunities.

SOT Poster Presentations in San Diego, March 27-31, 2022. We had three presentations at the Annual SOT meeting, including "Development of Canine Testicular Organoids for Assessing Male Reproductive Toxicity", "High-Content Imaging Analysis for Testicular Toxicity Prediction Using an 87-Compound Library in a Three-Dimensional Testicular Cell Co-culture Model", and "Establishment, Characterization, and Toxicological Application of Canine Primary Sertoli Cells".

Reprotox attended NMBio’s second annual Knowledge Fair & Expo in October 2021. We enjoyed meeting scientists, academic leaders, tech transfer specialists, entrepreneurs, business executives, venture capitalists, investors, and economic development professionals. We look forward to building strong relationships with industry colleagues in New Mexico.

Reprotox successfully relocated to Albuquerque, New Mexico from Athens, Georgia. We are excited about this improved R&D laboratory space within the UNM Science and Technology Park.

WC10 (the 10th World Congress on Alternatives and Animal Use in the Life Sciences) took place at the Washington State Convention Center in Seattle on August 20-24, 2017. Dr. Yu co-chaired the session on Models of Developmental and Reproductive Biology and presented "An Animal-Free In Vitro Three-Dimensional Testicular Cell Co-culture Model for Evaluating Male Reproductive Toxicants".